The cause of Alzheimer’s disease (AD) is unclear, and there is a significant need for better treatment of the disorder. Inflammation in the brain i.e. neuroinflammation, is an established hallmark of AD, but it is unclear precisely how neuroinflammation interacts with and/or exacerbates other types of AD pathology. We hypothesise that neuroinflammation exacerbates other types of AD pathology. This hypothesis has not been investigated before, and we hypothesise that these complex interactions may present a new treatment avenue. We will test this hypothesis using a novel mouse model which combines neuroinflammation with AD pathology. We will also examine a novel treatment for neuroinflammation, AD pathology and cognitive impairment in a mouse model. Our research will determine if interactions between neuroinflammation and AD pathology are a critical component of AD aetiology, and if these interactions could be a new treatment target.
Rose Chesworth a postdoctoral researcher at the School of Medicine, Western Sydney University.