The impact of modifiable risk factors on cognitive decline and Alzheimer’s disease dementia
As the search for a cure for Alzheimer's disease dementia remains unsuccessful, it is important to consider other ways to delay or prevent it. A range of modifiable risk factors, such as obesity, physical inactivity, low mood, disrupted sleep, social isolation and low cognitive engagement have been found to be related to cognitive impairment and dementia risk. However, most studies have only examined the contribution of these risk factors to cognitive dysfunction and dementia risk individually. As these risk factors are highly related to each other, a more comprehensive understanding of the contribution of modifiable risk factors to cognitive dysfunction and dementia risk would be achieved by examining the combined effects of these risk factors. The aim of the proposed project is to examine the additive or interactive contributions of each modifiable risk factor to determine their effect on cognitive dysfunction and dementia risk. The contribution of key genetic risk factors, such as the apolipoprotein E (APOE) E4 allele, to this relationship will also be explored. The results of this project will have the potential to inform the design of future multi-modal lifestyle intervention trials that aim to prevent or delay dementia.