Deferiprone to Delay Dementia (The 3D study): a clinical proof of concept study

Occurring Dates: 
30/01/2018 to 30/06/2021
Participant Duration: 
54 weeks
State of study: 
New South Wales
Victoria
Overview: 

This study is a phase 2, randomised, placebo-controlled, multicentre study to investigate the safety and efficacy of Deferiprone in participants with Alzheimer's disease. In this study, the investigators aim to determine whether Deferiprone (15 mg/kg BID orally) slows cognitive decline in Alzheimer's patients.

Florey Institute scientists have demonstrated that cognitive abilities like short term memory, executive function and language ability decline much faster in people with both high iron levels and high amyloid levels, than those with low brain iron levels who were also amyloid positive.

We are looking for adults to join the study, who:

  • Are aged over 65, or aged over 55 years and have been diagnosed with Alzheimer's disease or are amyloid positive
  • Have a reliable care support person for 12 months of the trial
  • Have demonstrated abnormal memory function in the last 6 months or at screening
  • If they have been on medication for symptomatic Alzheimer's disease, must be on a stable dose for the last 3 months

Participants will be screened for the study after signing the approved informed consent form. As part of the screening phase, subjects will undertake an extensive medical and neurological assessments as well as a PET and MRI scan.

Participants will need to take an oral medication (Deferiprone) twice a day for 52 weeks. Participants will return to the trial centre on Weeks 13, 26, 38, 52 to undertake a neurological examination as well as an assessment of blood samples taken at the visit. Participants must also attend weekly blood tests for the first 6 months of the trial, then fortnightly for the remaining 6 months. The blood test can be collected at pathology service near your place of residence.

Further Information: 

If you would like to participate or require further information you can contact David Baxendale at david.baxendale@florey.edu.au. Further information is also available on the study website.

This research has been approved by the Austin Hospital Human Research Ethics Committee (HREC/17/Austin/141).

Study Address: 
Austin Health PH: 03 9496 4238 Heidelberg Repatriation Hospital 300 Waterdale Road, Ivanhoe VIC
Box Hill PH: 03 9094 9542 5 Arnold Street Box Hill VIC
Alfred Hospital PH: 03 9076 2598 55 Commercial Road Prahran VIC
The Royal Melbourne Hospital PH: 03 9342 7572 300 Grattan Street Parkville VIC
The Hunter New England Health PH: 02 4033 5704 McAuley Centre, Waratah NSW
Full Name: 
Professor Ashley Bush
Institute: 
Florey Institute of Neurosciences and Mental Health
Email: 
ashley.bush@florey.edu.au
Phone Number: 
(03) 9035 6532