Investigating the impact of an online person-centred, multi-domain intervention program (BetterBrains) on cognitive decline

Occurring Dates
Participant Duration
The total trial duration is 2 years. All participants (intervention and control) will complete an initial assessment, followed by an assessment at 12 months and 24 months. Active intervention phase is 1 year.
State of study
All States

BetterBrains was born out of necessity. By the year 2050, it is projected that the number of people living with dementia will triple from 50 to 152 million, due to unprecedented population ageing. However, research estimates that approximately 35% of all dementia is attributable to risk factors that are highly modifiable, including low mood, poor sleep, poor heart health and low cognitive and social engagement.

The BetterBrains randomised controlled trial will test whether personalised lifestyle and educational behaviour change strategies targeted at modifying these four risk factors can prevent thinking and memory problems in middle-aged adults aged between 40 – 70 years. BetterBrains is one of the first clinical trials of dementia prevention globally to be delivered entirely online – meaning that you can participate in the trial regardless of where you are located in Australia.

The BetterBrains trial aims to recruit 1510 people living in the community throughout Australia. Of these people, 755 participants will be randomised to the intervention group and will receive the personalised BetterBrains program, while the other 755 participants will receive health education materials about dementia risk reduction.

What does participation involve?

Before you are able to enrol into the study, you will be asked to complete a series of screening questions to ensure that BetterBrains is safe and suitable for you. If the study is deemed safe and suitable for you, you will be asked to complete some additional online surveys about your health and wellbeing, as well as complete some memory and thinking tasks. You will be asked to complete these same surveys and the memory and thinking tests again at 12 and 24 months after your initial assessment.

After completing your initial assessment, you will then be allocated at random (you can think of this like tossing a coin) to one of two study groups. One group will receive the personalised healthy lifestyle intervention program which will also include telephone coaching provided by qualified clinicians (your ‘BetterBrains Coach’) and educational material regarding living a healthy lifestyle in order to improve your brain health. The other group will receive only the educational material.

Further information

To learn more about the BetterBrains trial, or to sign-up, please visit our website at Please pass on this invite to any friends or family members who you think may also be interested in participating. Lastly, if you have any questions about the BetterBrains trial, please contact our team at [email protected].

This project was approved by the Monash University Human Research Ethics committee (approval number: 25221).

Study Address
The study is entirely online. Visit for more information.
Full Name
Emily Rosenich
Turner Institute for Brain and Mental Health
Phone Number
0449 511 299