Optic Nerve Decline and Cognitive Change (ONDCC)

Occurring Dates
Participant Duration
One visit per year (3hrs) for 5 years
State of study
New South Wales

This project seeks to identify whether eye and brain tests can serve as early diagnostic markers for Alzheimer’s disease and dementia. We will evaluate the potential correlation of retinal, structural and functional changes within the eye to brain changes including cognitive decline and progression over a period of five years.

Participants must meet the following criteria:

  • 50+ years of age; and
  • No significant history of eye/vision disorders

By participating in this study, you will undergo a comprehensive ophthalmic examination, neuropsychological tests and Magnetic Resonance Imaging (MRI). We will also collect a small sample of blood to be analysed in the lab. Any abnormalities found from the ophthalmic and cognitive examinations will be referred for follow up by the study investigators. The study takes a maximum of 3 hrs, including pupil dilation with an additional 30-45min allocated for an MRI organised separately.

All participants will be reimbursed $40 for their time in participation in the form of a gift voucher.

Participation details

For further information or to participate, please contact Samran Sheriff on 0449 909 822 or at [email protected].

This study has been approved by the Macquarie University Human Research Ethics Committee (reference 52019553810900).

Study Address
2 Technology Place, Macquarie University NSW 2109
Full Name
Samran Sheriff
Macquarie University
Phone Number
0449 909 822