The Healthy Brain Project - an Australian-first online study of psychological, lifestyle and genetic factors that increase risk of Alzheimer’s disease

Occurring Dates: 
03/04/2017 to 01/01/2022
Participant Duration: 
3-4 hours per year for 5 years
State of study: 
All States

The main purpose of this study is to track the cognitive, lifestyle and psychological markers of 4000-5000 community-based middle-aged adults (40-65 years inclusive) over five years online, in relation to genetic risk factors that are shown to increase risk of Alzheimer’s disease dementia in older adults. We are interested in determining whether we can detect extremely subtle signs of memory and thinking changes in individuals who have elevated risk for Alzheimer’s disease dementia (e.g., have a family history of dementia and/or they have genetic signs of the disease). We also aim to determine additional risk and protective factors of the disease, so as to better inform future interventions and therapeutics.

We are looking for individuals aged between 40-65 years old (inclusive). Volunteers must be living in Australia, but do not need to be an Australian resident or citizen. Volunteers must be willing and able to complete surveys and computerised memory tasks online, and be willing to provide a saliva sample to allow us to conduct genotyping on key dementia genes.

This is a 5-year study. Participation in this study will involve yearly online assessment of cognitive function, and surveys pertaining to psychological health, lifestyle, medical health and family history. Saliva sampling kits will be mailed to participants (this will only occur once in this study).

Further Information: 

Please visit to learn more and to sign up to this study.

If you'd like to speak with a member of the research team, please call us at 0477 890 908, or email us at

This study is approved by the Royal Melbourne Hospital Human Research Ethics Committee (2016.199).

Study Address:
Full Name: 
Yen Ying Lim and Rachel Buckley
The Florey Institute of Neuroscience and Mental Health
Phone Number: 
+61 (0)477 890 908