Protein Changes that Underlie Selective Vulnerability in Alzheimer’s disease.
The aim of this research is to understand why some neurons are particularly vulnerable in Alzheimer’s disease. Determining why some neurons are vulnerable, and conversely why some neurons are protected, provides a unique opportunity to identify the protein changes that are responsible for the development of Alzheimer’s disease. This study will comprehensively profile the pathological protein changes that occur in vulnerable neurons in early stage Alzheimer’s disease. Specific protein changes that appear to be driving vulnerability in Alzheimer’s disease will be identified and additional experiments performed to determine how these specific protein changes lead to neuron death in Alzheimer’s disease. Results from this study will increase understanding about the cause of Alzheimer’s disease and will identify new drug targets for early stage Alzheimer’s disease.
Dr Drummond is the Bluesand Research Fellow at the Brain and Mind Centre at the University of Sydney.