Investigating how presenilin causes neurodegeneration in Alzheimer’s disease.
Memory loss in Alzheimer’s disease results from damage, and ultimately the death of brain cells. The sequence of events that underlies this toxicity is unknown, and understanding this could lead to new drugs. Based on our recent clinical findings, and our new understanding of how Alzheimer-associated proteins might contribute to cell damage, we plan to use laboratory models to establish a new mechanism of toxicity, and trial new therapeutics based on this concept.
Dr Ayton is a National Health and Medical Research Council – R.D. Wright Career Development Fellow, Deputy Director of the Melbourne Dementia Research Centre and Head of the Translational Neurodegeneration Laboratory at the Florey Institute of Neuroscience and Mental Health, University of Melbourne.