High-frequency sampling of cognition in clinically normal adults at genetic risk of Alzheimer’s disease using mobile applications.
Detecting the earliest signs of memory problems is critical for identifying individuals at-risk for dementia so that they can be given the opportunity to sign up for clinical trials and make lifestyle changes. Accurately measuring memory change is hard as memory can vary from day-to-day. Most studies measure memory annually, which is problematic because it assumes that individuals are in a similar state of mind every year (not fatigued, not stressed). One alternative is to increase the number of times an individual is tested to get a more accurate estimation of their memory. Unfortunately, many studies cannot implement this approach, as studies do lengthy and expensive tests in a clinic. Using two smartphone apps that we developed, we aim to determine the feasibility and reliability of high-frequency memory assessments. These apps have the potential to be one of the first of their kind to be implemented across large Alzheimer’s studies.
Dr Lim is a Senior Research Fellow and Head of the Cognitive Health and Ageing Outcomes (CHAOS) laboratory at the Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health and the University of Melbourne.