Brandon Munn

This research focuses on using advanced brain imaging and computational models to identify and understand early brain dysfunction in dementia, aiming to improve early detection and intervention strategies. It targets the locus coeruleus, a brain region crucial for arousal, attention and memory, which often shows signs of dysfunction before other symptoms of dementia appear. By combining innovative imaging techniques with physics-inspired computational methods, the study seeks to uncover unique brain activity patterns that signal cognitive decline. 

These findings will be linked to cellular processes, providing insights into how changes at the microscopic level impact overall brain function. The project also aims to develop open-source tools that researchers and clinicians can use to study a wide range of brain disorders. This work could lead to breakthroughs in early detection, allowing for timely and personalised treatment approaches that address dementia before significant cognitive decline occurs.

Dr. Brandon Munn is a Postdoctoral Research Fellow in the Shine Lab at the School of Medical Sciences, The University of Sydney. His research focuses on using physics-inspired techniques and mathematical modelling to uncover the multiscale organisation of the brain and its dysfunction in dementia.