Michael Wheeler

What is the focus of the research?

Investigating whether a short walk before using an insulin nasal spray can improve memory in people with mild cognitive impairment.

Why is this important?

Mild cognitive impairment is a high-risk stage for dementia, with around one in 10 people progressing to dementia each year. Treatments to slow memory decline at this stage are much needed. Insulin plays an important role in brain health and a nasal spray form allows it to reach the brain with minimal effects on blood sugar levels.

Earlier studies suggested intranasal insulin could improve memory, but a large trial showed no benefit and suggested insufficient insulin reached the brain. Dr Wheeler will investigate whether a short bout of exercise before administering the nasal spray can help the brain better absorb and use insulin by improving blood flow and brain responsiveness to insulin in people with mild cognitive impairment. If successful, this approach could strengthen guidelines that already endorse physical activity for brain health and support the development of a simple, low-cost strategy to slow cognitive decline.

What could it mean for people with mild cognitive impairment?

• A simple daily routine combining walking and a nasal spray to support memory.
• A low-cost, accessible approach that could be done at home.
• The potential to slow memory decline and delay the onset of dementia.

Dr Wheeler is a researcher at the Institute for Physical Activity and Nutrition, Deakin University. He also teaches science communication at The University of Melbourne and co-hosts the Let’s Talk SciComm podcast.