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Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease. The goal of the study is to learn if MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD & damages brain cells.

This study has been approved by a Belberry Human research ethics committee (2025-04-528)

Participation

People who meet the following criteria my be eligible to participate in the study; 

  • Aged 50 to 85 years 
  • Have a diagnosis of Mild Cognitive Impairment or Mild Alzheimer's dementia
  • Have a study partner who can come onsite for a few hours every 3 months
  • No other neurological condition

This trial goes for 2.4 years and involves monthly infusions. Participants will also need to have MRIs, PET scans, blood tests, and cognitive testing. 


Participant duration

Monthly participation for 2.4 years


Available to people living in

VIC


Study begins

Wednesday, 1 April 2026


Study ends

Sunday, 1 November 2026

Contact

To find out more about this study, contact:

Laura Margison

Austin Health

mcru.recruitment@austin.org.au

0403 110 157

Austin Repatriation Hospital 300 Waterdale Road, Ivanhoe 3079 , VIC

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Last updated
7 April 2026